Again using the wheel concept of the universe, the divinity of the universe is again separated in the Mesoamerican worldview- the outer ring being raw divinity (once again, Ometeotl), the middle ring being the realm of the gods, and the center ring being the physical world. As these wheels turn, the spiritual world interacts with the physical world, and it is from this concept that the Tonalpohualli (the sacred calendar or “Count of Fate”) was born. The gods may influence the physical world through their actions in the spiritual world, but they also may choose to act in the physical world itself. In addition, it is also possible for a person to gain access to the spiritual world. In any case, it is the gods, and not Ometeotl, who have conscious influence on the universe.

The Mesoamerican worldview does not have clear conceptions of good and evil, but rather light and dark. A dark thing does not mean an evil thing, nor is darkness to be avoided if it is in one's nature. Dark deities were revered just as much as light deities, and both dark and light forces were seen as necessary to the functioning of the universe. “Evil” is, more often than not, a term the Spaniards attached to the gods and rituals of a religion they saw as “idolatrous,” an unfortunate misrepresentation that persists today.

Conflict is seen as being of great importance to the universe; the conflicts between various deities and powers keep the universe in motion. Certain gods conflicted with each other often, but rather than seeing this in the black and white view of good vs. evil, the Aztecs saw these as necessary clashes between deities, and accepted it as something the gods simply do. Rather than perfection being seen as a continuous balance between all powers in all things, a cycling between unique powers was deemed healthy and necessary. It was believed that continuous and even balance would result in the stagnation of the universe; without the cycling of powers, the Ollin (motion principle) of the universe would be lost. And so, a healthy universal equilibrium was instead found by separate independent powers exerting their forces at different times, their cycling ensuring that these powers functioned to equal each other out while still keeping up the conflict necessary to the universe. This is an important aspect of both the Tonalpohualli and the Five Suns; where different deities hold more or less sway over the world at different times, making sure that all powers have their moment of influence.

The deities of the Aztec pantheon tend to be patrons of particular aspects of life and the universe. There is a sort of hierarchy among the gods, some being more powerful than others; however, unlike the pantheons of many civilizations, there was no "ruler" or head god. Instead, the gods were seen as being relatively autonomous; they could and would consult each other and unite in purpose if they deemed it necessary in some matter, but more often than not they acted in accordance with their own wills, different deities allying or conflicting with each other as they personally saw fit. In addition, the gods were seen as having their own motives in existence; they didn't simply exist to be the caretakers of humanity, or to fulfill a larger cosmic goal, although they did that as well. Rather, the gods were also seen as having their own individual, personal motives and plans, much like humans, but above and beyond the scope of human understanding. In the Aztec world, priests were dedicated to serving one deity in particular. In addition, most people, from the nobility to the commoners, chose a particular deity (or were chosen by that deity) to serve as their patron and whom they were particularly devoted to. Even so, all the gods were respected and revered by the people.